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interface:research [2017-11-08 22:55]
Markus Valtiner
interface:research [2017-11-09 20:44] (current)
Markus Valtiner
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====== Biointerfaces ====== ====== Biointerfaces ======
-===== Complex interfaces - Scaling of molecular interaction forces =====+===== Adhesion and forces at biointerphases - From one, to two, to many single molecular interactions =====
{{:interface:aip_bi_fig2.png?180 |Scaling of molecular interactions}} All active systems that are subject to change, motion or flow of matter (i.e. all biological systems, and all mechanical systems) are subject to fundamental forces that drive and steer the way in which atoms, molecules and ultimately macroscopic structures develop, evolve, adapt and age. In essence, **dynamic molecular interactions** //are everything//! Consequently, the study of interactive forces is a shared and fundamental interest in seemingly unrelated fields, such as biophysics and adhesion, or corrosion science and stem cell research. {{:interface:aip_bi_fig2.png?180 |Scaling of molecular interactions}} All active systems that are subject to change, motion or flow of matter (i.e. all biological systems, and all mechanical systems) are subject to fundamental forces that drive and steer the way in which atoms, molecules and ultimately macroscopic structures develop, evolve, adapt and age. In essence, **dynamic molecular interactions** //are everything//! Consequently, the study of interactive forces is a shared and fundamental interest in seemingly unrelated fields, such as biophysics and adhesion, or corrosion science and stem cell research.
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However, we still lack a detailed understanding how macroscopic properties dynamically evolve from molecular forces and interactions; examples include adhesive interactions or adaptive feedback-triggered interactions such as specific and redox-couple interactions. However, we still lack a detailed understanding how macroscopic properties dynamically evolve from molecular forces and interactions; examples include adhesive interactions or adaptive feedback-triggered interactions such as specific and redox-couple interactions.
We showed how it is possible to directly extrapolate a macroscopic work of adhesion based on single molecule Atomic Force Microscopy. We are now using this strategy to extend our understanding of adhesion and interactions at complex biologic interfaces. We showed how it is possible to directly extrapolate a macroscopic work of adhesion based on single molecule Atomic Force Microscopy. We are now using this strategy to extend our understanding of adhesion and interactions at complex biologic interfaces.
-===== Hydrophobic interactions and self assembly =====+===== Hydrophobic interactions, peptides at interfaces and self assembly =====
{{:interface:aip_bi_fig1.png?180 |Single molecule bond rupture}} {{:interface:aip_bi_fig1.png?180 |Single molecule bond rupture}}
Interactions between hydrophobic moieties steer ubiquitous processes in aqueous media, including the self-organization of biologic matter. Recent decades have seen tremendous progress in understanding these for macroscopic hydrophobic interfaces. Yet, it is still a challenge to experimentally measure **hydrophobic interactions at the single-molecule scale** and thus to compare with theory. Interactions between hydrophobic moieties steer ubiquitous processes in aqueous media, including the self-organization of biologic matter. Recent decades have seen tremendous progress in understanding these for macroscopic hydrophobic interfaces. Yet, it is still a challenge to experimentally measure **hydrophobic interactions at the single-molecule scale** and thus to compare with theory.
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We develop methods for the experimental characterization of single molecular hydrophobic interactions, and we directly compare our experiments with simulations at the molecular scale. Our main strategy is to examine precisely controllable sequences of interacting end-grafted hydrophobic peptides where interactions can be tuned with exact control using model repeat scaffolds. We develop methods for the experimental characterization of single molecular hydrophobic interactions, and we directly compare our experiments with simulations at the molecular scale. Our main strategy is to examine precisely controllable sequences of interacting end-grafted hydrophobic peptides where interactions can be tuned with exact control using model repeat scaffolds.
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====== Materials Interfaces ====== ====== Materials Interfaces ======
-===== Degradation and Corrosion =====+===== Degradation and corrosion =====
{{:interface:aip_mi_fig1.png?180 |}} What affects almost every man made modern material used in cars, aircrafts, pipelines and even the implants you may need at some point? Degradation, decay and ultimately complete loss of functionality! We try to understand degradation and we aim to slow it down significantlty. {{:interface:aip_mi_fig1.png?180 |}} What affects almost every man made modern material used in cars, aircrafts, pipelines and even the implants you may need at some point? Degradation, decay and ultimately complete loss of functionality! We try to understand degradation and we aim to slow it down significantlty.
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For instance for metals specifically, **corrosion** is an often surprisingly fast and unexpected process of inevitable decay. At an estimated cost of 3% of the GDP annually, it carries a steep price tag, not to mention, the potential safety, environmental and health hazards it poses. Our work focusses on understanding nano-to-microscale degradation mechanims and invention of unique real-time analysis methods for vizualizing the initial steps of corrosion of structural and functional metals and metal/polymer composites. Specifically, we are interested in corrosion in confinement, which is //crevice corrosion// and //pitting corrosion//: We aim to deliver models and predictions of how and when materials in confined spaces corrode, and how this corrosion can be slowed down. For instance for metals specifically, **corrosion** is an often surprisingly fast and unexpected process of inevitable decay. At an estimated cost of 3% of the GDP annually, it carries a steep price tag, not to mention, the potential safety, environmental and health hazards it poses. Our work focusses on understanding nano-to-microscale degradation mechanims and invention of unique real-time analysis methods for vizualizing the initial steps of corrosion of structural and functional metals and metal/polymer composites. Specifically, we are interested in corrosion in confinement, which is //crevice corrosion// and //pitting corrosion//: We aim to deliver models and predictions of how and when materials in confined spaces corrode, and how this corrosion can be slowed down.
interface/research.txt · Last modified: 2017-11-09 20:44 by Markus Valtiner