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Florian Baumgart

Florian BaumgartEmail: [email address: lastname @ this server · enable javascript to see it]
Phone: +43-(0)1-58801-134890

Current Research Interest

T cells have the fascinating ability to recognize foreign peptide structures with remarkable high specificity and sensitivity. On the molecular level, this is achieved by specific binding of the T cell receptor (TCR) to an antigenic peptide bound to the major histocompatibility complex (pMHC) on an antigen presenting cell. TCR-pMHC binding results in the recruitment of proximal signaling components and culminates in downstream signaling and T cell activation. It is believed that the spatial organization of the TCR and components of proximal T cell signaling on the T cell plasma membrane is crucial for sensitive and specific antigen recognition. In my work, I want to get a better understanding of how the different molecular players at the T cell plasma membrane cooperate to identify potential threats. I use single molecule techniques, like superresolution microscopy and single molecular tracking, to get insights into the molecular arrangement of components of early T cell signaling. The most important model system for my work are transgenic primary murine T cells, where specific TCR-pMHC interactions can be used to study T cell activation.

Curriculum vitae

biophysics/group/baumgart.txt · Last modified: 2014-09-19 11:23 by Viktoria Motsch